COPS3/CSN3 Recombinant Rabbit Monoclonal Antibody [JE47-48]
Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively.
Product Specifications
CAS Number
9000-83-3
Product Name Alternative
Abbreviation
SGN3, Signalosome subunit 3, COPS3, CSN3
Swiss Prot
Q9UNS2 Human, O88543 Mouse, Q68FW9 Rat
Cellular Locus
Cytoplasm. Nucleus.
Host
Rabbit
Species Reactivity
Human,Mouse,Rat
Immunogen
Recombinant protein within Human COPS3 / CSN3 aa 280-423 / 423.
Isotype
IgG
Conjugation
Non-conjugated
Type
Recombinant Rabbit monoclonal Antibody
Applications
WB, IF-Cell, IHC-P, FC
Positive Control
Concentration
1 mg/mL
Dilution
WB:1:500-1:1,000;IF-Cell:1:500-1:2,000;IHC-P:1:50-1:200;FC:1:50-1:100
Purity
Protein A affinity purified.
Form
Liquid
Buffer
1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Molecular Weight
Predicted band size: 48 kDa
Storage Conditions
Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
Recombinant Antibody
Yes
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