CLASP1 Recombinant Rabbit Monoclonal Antibody [JE43-19]
Microtubule plus-end tracking protein that promotes the stabilization of dynamic microtubules. Involved in the nucleation of noncentrosomal microtubules originating from the trans-Golgi network (TGN). Required for the polarization of the cytoplasmic microtubule arrays in migrating cells towards the leading edge of the cell. May act at the cell cortex to enhance the frequency of rescue of depolymerizing microtubules by attaching their plus-ends to cortical platforms composed of ERC1 and PHLDB2. This cortical microtubule stabilizing activity is regulated at least in part by phosphatidylinositol 3-kinase signaling. Also performs a similar stabilizing function at the kinetochore which is essential for the bipolar alignment of chromosomes on the mitotic spindle.
Product Specifications
CAS Number
9000-83-3
Product Name Alternative
Abbreviation
hOrbit1, CLASP1, KIAA0622, MAST1
Swiss Prot
Q7Z460 Human, Q80TV8 Mouse,
Cellular Locus
Cytoskeleton, Golgi apparatus.
Host
Rabbit
Species Reactivity
Human,Mouse,Rat
Immunogen
Synthetic peptide within Human CLASP1 aa 1-50 / 1,538.
Isotype
IgG
Conjugation
Non-conjugated
Type
Recombinant Rabbit monoclonal Antibody
Applications
WB, IF-Cell, IF-Tissue, IHC-P, FC
Positive Control
HepG2 cell lysate, Daudi cell lysate, SH-SY-5Y, SiHa, rat kidney tissue, human stomach tissue, human small intestine tissue, mouse colon tissue.
Concentration
1 mg/mL
Dilution
WB:1:500-1:2,000 ;IF-Cell:1:50-1:200 ;IF-Tissue:1:50-1:200 ;IHC-P:1:50-1:1,000 ;FC:1:50-1:100
Purity
Protein A affinity purified.
Form
Liquid
Buffer
1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Molecular Weight
Predicted band size: 169 kDa
Storage Conditions
Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
Recombinant Antibody
Yes
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