STUB1 Recombinant Rabbit Monoclonal Antibody [JG38-22]

CHIP (carboxy terminus of HSP 70-interacting protein), also designated STIP1 homology and U-box containing protein 1, HSPABP2, NY-CO-7, SDCCAG7 and STUB1, is a cytoplasmic E3 ubiquitin ligase that influences protein ubiquitylation. CHIP interacts with Smad1/Smad4 and blocks BMP signaling through the ubiquitin-mediated degradation of Smad proteins. CHIP controls both association of Hsp70/Hsp90 chaperones with ErbB2 and down-regulation of ErbB2 induced by inhibitors of Hsp90. A 1.3-kb transcript is most abundant in striated muscle (heart and skeletal muscle), with lower expression in pancreas and brain.

Product Specifications

CAS Number

9000-83-3

Product Name Alternative

Antigen NY CO 7 antibody Antigen NY-CO-7 antibody C terminus of Hsp70-interacting protein antibody Carboxy terminus of Hsp70 interacting protein antibody Carboxy terminus of Hsp70-interacting protein antibody Carboxy terminus of Hsp70p interacting protein antibody CHIP antibody CHIP_HUMAN antibody CLL associated antigen KW 8 antibody CLL-associated antigen KW-8 antibody E3 ubiquitin protein ligase CHIP antibody E3 ubiquitin-protein ligase CHIP antibody Heat shock protein A binding protein 2 (c terminal) antibody HSPABP2 antibody NY CO 7 antibody PP1131 antibody SDCCAG7 antibody Serologically defined colon cancer antigen 7 antibody STIP1 homology and U Box containing protein 1 antibody STIP1 homology and U box containing protein 1 E3 ubiquitin protein ligase antibody STIP1 homology and U box-containing protein 1 antibody STUB 1 antibody STUB1 antibody UBOX 1 antibody UBOX1 antibody

Abbreviation

STUB1, CHIP, PP1131

Swiss Prot

Q9UNE7 Human, Q9WUD1 Mouse,

Cellular Locus

Nucleus. Cytoplasm.

Host

Rabbit

Species Reactivity

Human,Mouse,Rat

Immunogen

Synthetic peptide within Human STUB1 aa 10-59 / 303.

Isotype

IgG

Conjugation

Non-conjugated

Type

Recombinant Rabbit monoclonal Antibody

Applications

WB, IF-Cell, IHC-P, IP, FC

Positive Control

HeLa cell lysate, HEK-293 cell lysate, human brain tissue lysate, human heart tissue, mouse heart tissue, rat heart tissue, 293T, LOVO, MCF-7, SH-SY5Y.