Bcl-6 Recombinant Rabbit Monoclonal Antibody [JB18-48]
Bcl-6, a transcriptional repressor, binds Stat recognition-like DNA elements and influences germinal center development and Th1/Th2 differentiation. Bcl-6 negatively regulates NFkB expression, thereby inhibiting NFkB-mediated cellular functions. HDAC- and silent information regulator (SIR)-2-dependent acet-ylation of Bcl-6 causes downregulation of activity by inhibiting the ability of Bcl-6 to recruit complexes containing histone deacetylases (HDACs). Bcl-6 is frequently deregulated in non-Hodgkin's B cell lymphomas. The human BCL6 gene has been shown to encode a protein of 706 amino acids.
Product Specifications
CAS Number
9000-83-3
Product Name Alternative
Abbreviation
BCL-6, BCL-5, BCL6, BCL5, LAZ3, ZBTB27, ZNF51
Swiss Prot
P41182 Human, P41183 Mouse
Cellular Locus
Nucleus.
Host
Rabbit
Species Reactivity
Mouse,Human
Immunogen
Synthetic peptide within Human Bcl-6 aa 657-706 / 706.
Isotype
IgG
Conjugation
Non-conjugated
Type
Recombinant Rabbit monoclonal Antibody
Applications
WB
Positive Control
NIH/3T3.
Concentration
1 mg/mL
Dilution
WB: 1:1,000-1:5,000
Purity
Protein A affinity purified.
Form
Liquid
Buffer
1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Molecular Weight
Predicted band size: 79 kDa
Storage Conditions
Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Recombinant Antibody
Yes
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