Bcl-6 Recombinant Rabbit Monoclonal Antibody [JB18-48]

Bcl-6, a transcriptional repressor, binds Stat recognition-like DNA elements and influences germinal center development and Th1/Th2 differentiation. Bcl-6 negatively regulates NFkB expression, thereby inhibiting NFkB-mediated cellular functions. HDAC- and silent information regulator (SIR)-2-dependent acet-ylation of Bcl-6 causes downregulation of activity by inhibiting the ability of Bcl-6 to recruit complexes containing histone deacetylases (HDACs). Bcl-6 is frequently deregulated in non-Hodgkin's B cell lymphomas. The human BCL6 gene has been shown to encode a protein of 706 amino acids.

Product Specifications

CAS Number

9000-83-3

Product Name Alternative

B Cell Lymphoma 6 Protein antibody B-cell CLL/lymphoma 6 antibody B-cell lymphoma 5 protein antibody B-cell lymphoma 6 protein transcript antibody BCL5 antibody BCL6A antibody cys-his2 zinc finger transcription factor antibody LAZ3 antibody lymphoma-associated zinc finger gene on chromosome 3 antibody Protein LAZ-3 antibody ZBTB27 antibody Zinc finger and BTB domain-containing protein 27 antibody Zinc Finger Protein 51 antibody zinc finger transcription factor BCL6S antibody ZNF51 antibody