STIP1 Recombinant Rabbit Monoclonal Antibody [JB95-38]
Stress-induced-phosphoprotein 1 (STI1) functions as a co-chaperone for HSP70 and HSP90 during heat shock response. STI1 exists as either a monomer or a dimer, and this conformational flexibility facilitates its function in organizing HSP70/HSP90. HSP90 acts as an ATPase, and requires the recruitment of client proteins and proper conformation to function. STI1 acts as a "scaffold" for client protein recruitment to the relaxed, ADP-bound conformation of HSP90, thus suppressing ATP turnover during the loading phase and allowing proper function.
Product Specifications
CAS Number
9000-83-3
Product Name Alternative
Abbreviation
STI1, Hop, STIP1
Swiss Prot
P31948 Human, Q60864 Mouse, O35814 Rat
Cellular Locus
Cytoplasm, Nucleus.
Host
Rabbit
Species Reactivity
Human,Mouse,Rat
Immunogen
Recombinant protein within Human STIP1 aa 1-137 / 543.
Isotype
IgG
Conjugation
Non-conjugated
Type
Recombinant Rabbit monoclonal Antibody
Applications
WB, IHC-P, FC, IF-Cell, IP
Positive Control
Mouse testis tissue, rat testis tissue lysate, human colon cancer tissue, human spleen tissue, K562.
Concentration
1 mg/mL
Dilution
WB: 1:500-1:1,000;IHC-P: 1:50-1:200;FC: 1:50-1:100;IF-Cell: 1:50;IP: Use at an assay dependent concentration.
Purity
Protein A affinity purified.
Form
Liquid
Buffer
1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Molecular Weight
Predicted band size: 63 kDa
Storage Conditions
Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Recombinant Antibody
Yes
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