HSD11B1 Recombinant Rabbit Monoclonal Antibody [JU18-39]
HSD11B1 (Corticosteroid 11-beta-dehydrogenase isozyme 1) is also named as HSD11, HSD11L,11-DH and 11-beta-HSD1.It is a microsomal enzyme, which acts mainly as a NADP (H)- dependent reductase converting inactive cortisone (E) to active cortisol (F), thus regulating intracellular F access to glucocorticoid receptor. This enzyme is widely expressed not only in liver and adipose tissue, but also in adrenal, ovary and decidua.Western blot analysis in human liver, using a specific11-beta-HSD1 antibody, showed two bands at approximately 34 and 68 kDa confrming the dimeric nature of 11-beta-HSD1 in liver and In omental adipose tissue, an additional band of 50 kDa was strongly expressed.
Product Specifications
CAS Number
9000-83-3
Product Name Alternative
Abbreviation
11-DH, 11-beta-HSD1, HSD11B1, HSD11, HSD11L, SDR26C1
Swiss Prot
P28845 Human, P50172 Mouse, P16232 Rat
Cellular Locus
Endoplasmic reticulum, Membrane.
Host
Rabbit
Species Reactivity
Human,Mouse,Rat
Immunogen
Synthetic peptide within Human HSD11B1 aa 1-50 / 292.
Isotype
IgG
Conjugation
Non-conjugated
Type
Recombinant Rabbit monoclonal Antibody
Applications
WB, IHC-P
Positive Control
Mouse liver tissue lysate, Rat liver tissue lysate, human liver tissue, mouse liver tissue.
Concentration
1 mg/mL
Dilution
WB: 1:2,000 ;IHC-P: 1:50-1:200
Purity
Protein A affinity purified.
Form
Liquid
Buffer
1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Molecular Weight
Predicted band size: 32 kDa
Storage Conditions
Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Recombinant Antibody
Yes
Frequently Asked Questions
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