Fragilis Recombinant Rabbit Monoclonal Antibody [JU73-02]
Interferon-induced transmembrane protein 3 (IFITM3) is a protein that in humans is encoded by the IFITM3 gene. It plays a critical role in the immune system's defense against Swine Flu, where heightened levels of IFITM3 keep viral levels low, and the removal of IFITM3 allows the virus to multiply unchecked. This observation has been further advanced by a recent study from Paul Kellam's lab that shows that a single nucleotide polymorphism in the human IFITM3 gene purported to increase influenza susceptibility is overrepresented in people hospitalised with pandemic H1N1. The prevalence of this mutation is thought to be approximately 1/400 in European populations.
Product Specifications
CAS Number
9000-83-3
Product Name Alternative
Abbreviation
DSPA2b, IFITM3
Swiss Prot
Q01628 Human
Cellular Locus
Cell membrane, Late endosome membrane, Lysosome membrane, perinuclear region.
Host
Rabbit
Species Reactivity
Human
Immunogen
Synthetic peptide within Human Fragilis aa 1-50 / 133.
Isotype
IgG
Conjugation
Non-conjugated
Type
Recombinant Rabbit monoclonal Antibody
Applications
WB, IF-Cell, IF-Tissue, IHC-P, FC
Positive Control
HepG2 cell lysate, HeLa cell lysate, THP-1 cell lysate, HeLa, human breast cancer tissue, human colon cancer tissue, MCF-7.
Concentration
1 mg/mL
Dilution
WB: 1:2,000 ;IF-Cell: 1:100 ;IF-Tissue: 1:50-1:200 ;IHC-P: 1:1,000 ;FC: 1:50-1:100
Purity
Protein A affinity purified.
Form
Liquid
Buffer
1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Molecular Weight
Predicted band size: 15 kDa
Storage Conditions
Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Recombinant Antibody
Yes
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