OPA1 Recombinant Rabbit Monoclonal Antibody [JM81-35]

Dynamin-related GTPase that is essential for normal mitochondrial morphology by regulating the equilibrium between mitochondrial fusion and mitochondrial fission .Coexpression of isoform 1 with shorter alternative products is required for optimal activity in promoting mitochondrial fusion.Binds lipid membranes enriched in negatively charged phospholipids, such as cardiolipin, and promotes membrane tubulation.The intrinsic GTPase activity is low, and is strongly increased by interaction with lipid membranes.Plays a role in remodeling cristae and the release of cytochrome c during apoptosis.Proteolytic processing in response to intrinsic apoptotic signals may lead to disassembly of OPA1 oligomers and release of the caspase activator cytochrome C (CYCS) into the mitochondrial intermembrane space. Plays a role in mitochondrial genome maintenance.