Klotho Recombinant Rabbit Monoclonal Antibody [JM93-76]
May have weak glycosidase activity towards glucuronylated steroids. However, it lacks essential active site Glu residues at positions 239 and 872, suggesting it may be inactive as a glycosidase in vivo. May be involved in the regulation of calcium and phosphorus homeostasis by inhibiting the synthesis of active vitamin D. Essential factor for the specific interaction between FGF23 and FGFR1. The Klotho peptide generated by cleavage of the membrane-bound isoform may be an anti-aging circulating hormone which would extend life span by inhibiting insulin/IGF1 signaling.
Product Specifications
CAS Number
9000-83-3
Product Name Alternative
Kl antibody KLOT_HUMAN antibody Klotho peptide antibody
Abbreviation
KL
Swiss Prot
Q9UEF7 Human, O35082 Mouse
Cellular Locus
Cell membrane. Apical cell membrane. Secreted.
Host
Rabbit
Species Reactivity
Human,Mouse
Immunogen
Synthetic peptide within Human Klotho aa 404-453 / 1,012.
Isotype
IgG
Conjugation
Non-conjugated
Type
Recombinant Rabbit monoclonal Antibody
Applications
WB, IHC-P
Positive Control
Human kidney tissue lysates, Human serum lysate, human kidney tissue lysate, human kidney tissue, mouse kidney tissue.
Concentration
1 mg/mL
Dilution
WB: 1:500-1:5,000 ;IHC-P: 1:50-1:200
Purity
Protein A affinity purified.
Form
Liquid
Buffer
1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Molecular Weight
Predicted band size: 116 kDa
Storage Conditions
Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Recombinant Antibody
Yes
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