DNA Ligase IV Recombinant Rabbit Monoclonal Antibody [JM64-32]
The X-ray repair cross-complementing protein XRCC4 and DNA Ligase IV are essential for repairing double-strand breaks in DNA. These stories form a critical complex composed of two molecules of each protein that preferentially bind DNA with nicks or broken ends. As an obligatory accessory molecule, XRCC4 binds to DNA Ligase IV and enhances its joining activity. The XRCC4 / DNA Ligase IV complex is also involved in V (D) J recombination. V (D) (in) a pair of high incidence of apoptosis in the development nervous system and a block in B and T cell maturation.
Product Specifications
CAS Number
9000-83-3
Product Name Alternative
Abbreviation
LIG4
Swiss Prot
P49917 Human
Cellular Locus
Nucleus.
Host
Rabbit
Species Reactivity
Human
Immunogen
Recombinant protein within Human DNA Ligase IV aa 484-705 / 911.
Isotype
IgG
Conjugation
Non-conjugated
Type
Recombinant Rabbit monoclonal Antibody
Applications
WB, IHC-P, IF-Cell
Positive Control
HepG2 cell lysate, Hela cell lysate, Jurkat cell lysate, human colon carcinoma tissue, human placenta tissue.
Concentration
1 mg/mL
Dilution
WB: 1:500-1:2,000 ;IHC-P: 1:50-1:200 ;IF-Cell: 1:10-1:50
Purity
Protein A affinity purified.
Form
Liquid
Buffer
1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Molecular Weight
Predicted band size: 104 kDa
Storage Conditions
Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Recombinant Antibody
Yes
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