TXNIP Recombinant Rabbit Monoclonal Antibody [JM60-35]

May act as an oxidative stress mediator by inhibiting thioredoxin activity or by limiting its bioavailability. Interacts with COPS5 and restores COPS5-induced suppression of CDKN1B stability, blocking the COPS5-mediated translocation of CDKN1B from the nucleus to the cytoplasm. Functions as a transcriptional repressor, possibly by acting as a bridge molecule between transcription factors and corepressor complexes, and over-expression will induce G0/G1 cell cycle arrest. Required for the maturation of natural killer cells.

Product Specifications

CAS Number

9000-83-3

Product Name Alternative

EST01027 antibody HHCPA78 antibody THIF antibody Thioredoxin binding protein 2 antibody Thioredoxin interacting protein antibody Thioredoxin-binding protein 2 antibody Thioredoxin-interacting protein antibody TXNIP antibody TXNIP_HUMAN antibody Upregulated by 1,25 dihydroxyvitamin D 3 antibody VDUP1 antibody Vitamin D3 up-regulated protein 1 antibody

Abbreviation

TXNIP, VDUP1

Swiss Prot

Q9H3M7 Human, Q8BG60 Mouse, Q5M7W1 Rat

Cellular Locus

Cytoplasm.

Host

Rabbit

Species Reactivity

Human,Mouse,Rat

Immunogen

Synthetic peptide within Human TXNIP aa 50-99 / 391.

Isotype

IgG

Conjugation

Non-conjugated

Type

Recombinant Rabbit monoclonal Antibody

Applications

WB, IF-Cell, IF-Tissue, IHC-P, FC

Positive Control

HeLa cell lysate, NIH/3T3 cell lysate, PC-12 cell lysate, mouse stomach tissue lysate, mouse kidney tissue lysate, PC-12, human kidney tissue, mouse kidney tissue, rat kidney tissue, human stomach tissue, mouse esophagus tissue, mouse stomach tissue.