MRP2 Recombinant Rabbit Monoclonal Antibody [JA32-01]
Multi-drug resistance protein 2 (MRP2), also known as ABCC2, is an ATP binding cassette (ABC) transporter responsible for biliary excretion of xenobiotics, endobiotics, and their metabolites. Deficiency in ABCC2 results in the clinical disorder Dubin-Johnson syndrome. MRP2 is found to be expressed in a variety of human cancers, and is associated with resistance of tumor cells to various anticancer drugs including cisplatin. The predicted molecular weight of MRP2 is 174 kDa, while mature MRP2 usually has a slower migration around 190-250 kDa due to the glycosylation.
Product Specifications
CAS Number
9000-83-3
Product Name Alternative
Abbreviation
ABCC2, CMOAT, CMOAT1, CMRP, MRP2
Swiss Prot
Q92887 Human
Cellular Locus
Apical cell membrane.
Host
Rabbit
Species Reactivity
Human
Immunogen
Synthetic peptide within Human MRP2 aa 1496-1545 / 1545.
Isotype
IgG
Conjugation
Non-conjugated
Type
Recombinant Rabbit monoclonal Antibody
Applications
WB, IF-Cell, IHC-P, FC
Positive Control
HepG2 cell lysate, A549 cell lysate, HeLa cell lysate, HepG2, 293T, human liver tissue, human kidney tissue, human pancreas tissue, A549.
Concentration
1 mg/mL
Dilution
WB: 1:2,000 ;IF-Cell: 1:50-1:200 ;IHC-P: 1:50-1:800 ;FC: 1:50-1:100
Purity
Protein A affinity purified.
Form
Liquid
Buffer
1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Molecular Weight
Predicted band size: 174 kDa
Storage Conditions
Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Recombinant Antibody
Yes
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