GBA Recombinant Rabbit Monoclonal Antibody [JM10-76]
β-Glucosidase is a predominantly liver enzyme which efficiently hydrolyzes β-D-glucoside and β-D-galactoside. Defects in β-glucosidase cause Gaucher disease, an inherited condition distinguished by the accumulation of glucosylceramide within the cells of the reticuloendothelial system. β-Glucosidase is used in enzyme replacement treatment aimed at treating Gaucher disease. The absorption of dietary flavonoid glycosides in humans involves a critical deglycosylation step that is mediated by epithelial β-glucosidases.
Product Specifications
CAS Number
9000-83-3
Product Name Alternative
Abbreviation
Beta-GC, GBA
Swiss Prot
P04062 Human, P17439 Mouse,
Cellular Locus
Lysosome membrane.
Host
Rabbit
Species Reactivity
Human,Mouse,Rat
Immunogen
Synthetic peptide within Human GBA aa 477-534 / 536.
Isotype
IgG
Conjugation
Non-conjugated
Type
Recombinant Rabbit monoclonal Antibody
Applications
WB, IHC-P
Positive Control
U-87 MG cell lysates, human kidney tissue, human brain tissue, rat brain tissue, mouse pancreas tissue.
Concentration
1 mg/mL
Dilution
WB: 1:2,000 ;IHC-P: 1:50-1:500
Purity
Protein A affinity purified.
Form
Liquid
Buffer
1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Molecular Weight
Predicted band size: 60 kDa
Storage Conditions
Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Recombinant Antibody
Yes
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