CD59 Recombinant Rabbit Monoclonal Antibody [JM10-71]

CD59 glycoprotein, also known as MAC-inhibitory protein (MAC-IP), membrane inhibitor of reactive lysis (MIRL), or protectin, is a protein that in humans is encoded by the CD59 gene. It is an LU domain and belongs to the LY6/uPAR/alpha-neurotoxin protein family. CD59 attaches to host cells via a glycophosphatidylinositol (GPI) anchor. When complement activation leads to deposition of C5b678 on host cells, CD59 can prevent C9 from polymerizing and forming the complement membrane attack complex. It may also signal the cell to perform active measures such as endocytosis of the CD59-C9 complex. Mutations affecting GPI that reduce expression of CD59 and decay-accelerating factor on red blood cells result in paroxysmal nocturnal hemoglobinuria. Viruses such as HIV, human cytomegalovirus and vaccinia incorporate host cell CD59 into their own viral envelope to prevent lysis by complement.

Product Specifications

CAS Number

9000-83-3

Product Name Alternative

16.3A5 antibody 1F5 antibody 1F5 antigen antibody 20 kDa homologous restriction factor antibody CD 59 antibody CD_antigen=CD59 antibody CD59 antibody CD59 antigen antibody CD59 antigen complement regulatory protein antibody CD59 antigen p18 20 antibody CD59 antigen p18-20 (antigen identified by monoclonal antibodies 16.3A5, EJ16, EJ30, EL32 and G344) antibody CD59 glycoprotein antibody CD59 molecule antibody CD59 molecule complement regulatory protein antibody CD59_HUMAN antibody Cd59a antibody Complement regulatory protein antibody EJ16 antibody EJ30 antibody EL32 antibody FLJ38134 antibody FLJ92039 antibody G344 antibody HRF 20 antibody HRF-20 antibody HRF20 antibody Human leukocyte antigen MIC11 antibody Ly 6 like protein antibody Lymphocytic antigen CD59/MEM43 antibody MAC inhibitory protein antibody MAC IP antibody MAC-inhibitory protein antibody MAC-IP antibody MACIF antibody MACIP antibody MEM43 antibody MEM43 antigen antibody Membrane attack complex (MAC) inhibition factor antibody Membrane attack complex inhibition factor antibody Membrane inhibitor of reactive lysis antibody MGC2354 antibody MIC11 antibody MIN1 antibody MIN2 antibody MIN3 antibody MIRL antibody MSK21 antibody p18 20 antibody Protectin antibody Surface antigen recognized by monoclonal antibody 16.3A5 antibody T cell activating protein antibody

Abbreviation

HRF-20, HRF20, MAC-IP, MACIF, MIRL, CD59

Swiss Prot

P13987 Human, O55186 Mouse

Cellular Locus

Cell membrane. Secreted.

Host

Rabbit

Species Reactivity

Human,Mouse

Immunogen

Synthetic peptide within Human CD59 aa 85-121 / 128.

Isotype

IgG

Conjugation

Non-conjugated

Type

Recombinant Rabbit monoclonal Antibody

Applications

WB, IP

Positive Control

Human placenta tissue lysate, HUVEC cell lysate, K562 cell lysate, HUVEC, JAR, NIH/3T3.

Concentration

1 mg/mL

Dilution

WB: 1:1,000-1:5,000 ;IP: 1:10-1:50

Purity

Protein A affinity purified.

Form

Liquid

Buffer

1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Molecular Weight

Predicted band size: 14 kDa

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Recombinant Antibody

Yes

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