beta 2 Adrenergic Receptor Recombinant Rabbit Monoclonal Antibody [JM102-06]
The beta-2 adrenergic receptor (β2 adrenoreceptor), also known as ADRB2, is a cell membrane-spanning beta-adrenergic receptor that binds epinephrine (adrenaline), a hormone and neurotransmitter whose signaling, via adenylate cyclase stimulation through trimeric Gs proteins, increased cAMP, and downstream L-type calcium channel interaction, mediates physiologic responses such as smooth muscle relaxation and bronchodilation. The ADRB2 gene is intronless. Different polymorphic forms, point mutations, and/or downregulation of this gene are associated with nocturnal asthma, obesity and type 2 diabetes.
Product Specifications
CAS Number
9000-83-3
Product Name Alternative
Abbreviation
ADRB2
Swiss Prot
P07550 Human, P18762 Mouse, P10608 Rat
Cellular Locus
Cell membrane, Early endosome.
Host
Rabbit
Species Reactivity
Human,Mouse,Rat,Zebrafish
Immunogen
Synthetic peptide within Human ADRB2 aa 369-400 / 413.
Isotype
IgG
Conjugation
Non-conjugated
Type
Recombinant Rabbit monoclonal Antibody
Applications
WB, IHC-P, IP, IF-Cell, FC, IHC-Fr
Positive Control
Concentration
1 mg/mL
Dilution
WB: 1:5,000-1:20,000 ;IHC-P: 1:200-1:5,000 ;IP: Use at an assay dependent concentration. ;IF-Cell: 1:100 ;FC: 1:1,000 ;IHC-Fr: 1:500
Purity
Protein A affinity purified.
Form
Liquid
Buffer
1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Molecular Weight
Predicted band size: 46 kDa
Storage Conditions
Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Recombinant Antibody
Yes
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