CD74 Recombinant Rabbit Monoclonal Antibody [JF40-10]
The human histocompatibility leukocyte antigen (HLA) class II-associated invariant chain is composed of at least four polypeptides. One of these polypeptide chains is expressed as a membrane-bound subunit and has been designated CD74. The loading of peptide onto the class II MHC protein (MHC II) appears to be regulated by CD74, which associates with MHC II during its migration to the endosomal compartment, where class II binds pep-tide. CD74 is expressed by cells of both T lymphocyte and B lymphocyte lineages. In fact, CD74 is broadly expressed in normal B lymphocytes, regardless of their histocompatibility leukocyte antigen (HLA) phenotype, while a subset of peripheral T lymphocytes that are MHC II negative do not express CD74.
Product Specifications
CAS Number
9000-83-3
Product Name Alternative
Abbreviation
Ii, CD74
Swiss Prot
P04233 Human
Cellular Locus
Endoplasmic reticulum membrane, trans-Golgi network, cell membrane, lysosome, endosome.
Host
Rabbit
Species Reactivity
Human
Immunogen
Synthetic peptide within Human CD74 aa 21-64 / 296.
Isotype
IgG
Conjugation
Non-conjugated
Type
Recombinant Rabbit monoclonal Antibody
Applications
WB, IF-Cell, IF-Tissue, IHC-P, FC
Positive Control
Raji cell lysate, Jurkat cell lysate, Raji, human spleen tissue, human lymph nodes tissue, human tonsil tissue.
Concentration
1 mg/mL
Dilution
WB: 1:1,000-1:5,000 ;IF-Cell: 1:50-1:200 ;IF-Tissue: 1:50-1:500 ;IHC-P: 1:500 ;FC: 1:1,000
Purity
Protein A affinity purified.
Form
Liquid
Buffer
1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Molecular Weight
Predicted band size: 34 kDa
Storage Conditions
Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Recombinant Antibody
Yes
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