VAMP8 Recombinant Rabbit Monoclonal Antibody [JF0963]
Vesicle-associated membrane protein 8 is a protein that in humans is encoded by the VAMP8 gene.Synaptobrevins/VAMPs, syntaxins, and the 25-kD synaptosomal-associated protein SNAP25 are the main components of a protein complex involved in the docking and/or fusion of synaptic vesicles with the presynaptic membrane. The protein encoded by this gene is a member of the vesicle-associated membrane protein (VAMP)/synaptobrevin family. It is associated with the perinuclear vesicular structures of the early endocytic compartment. It has been found that VAMP8 interacts specifically with the soluble NSF-attachment protein (alpha-SNAP), most likely through an VAMP8-containing SNARE complex.Phosphorylation of VAMP8 inside the conserved SNARE-domain can suppress vesicle fusion.
Product Specifications
CAS Number
9000-83-3
Product Name Alternative
Abbreviation
VAMP-8, EDB, VAMP8
Swiss Prot
Q9BV40 Human, O70404 Mouse, Q9WUF4 Rat
Cellular Locus
Lysosome membrane, Early endosome membrane, Late endosome membrane, Cell membrane.
Host
Rabbit
Species Reactivity
Human,Mouse,Rat
Immunogen
Synthetic peptide wiithin Human VAMP8 aa1-29 / 100.
Isotype
IgG
Conjugation
Non-conjugated
Type
Recombinant Rabbit monoclonal Antibody
Applications
WB, IF-Cell, IF-Tissue, IHC-P, IP, FC
Positive Control
Hela cell lysate, mouse kidney tissue lysate, U937 cell lysates, SW480, 293T, Hela, human kidney tissue, mouse kidney tissue, rat kidney tissue.
Concentration
1 mg/mL
Dilution
WB: 1:1,000-1:2,000 ;IF-Cell: 1:50-1:100 ;IF-Tissue: 1:1,000 ;IHC-P: 1:5,000 ;FC: 1:50-1:100
Purity
Protein A affinity purified.
Form
Liquid
Buffer
1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Molecular Weight
Predicted band size: 11 kDa
Storage Conditions
Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Recombinant Antibody
Yes
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