Insulin degrading enzyme Recombinant Rabbit Monoclonal Antibody [JJ0949]
Insulin degrading enzyme (IDE), also known as insulinase, insulin protease or insulysin, cleaves the peptide hormone insulin with consequences for insulin response and resistance. IDE is a highly conserved thiol metalloprotease with ubiquitous expression including the brain. Since its discovery, IDE has been shown to degrade a variety of bioactive peptides. Recently the finding that IDE clears intracellular and extracellular amyloid products has spurred research into the link between IDE function and human neurodegenerative disease such as Alzheimer’s.
Product Specifications
CAS Number
9000-83-3
Product Name Alternative
Abbreviation
Insulinase, IDE
Swiss Prot
P14735 Human, Q9JHR7 Mouse, P35559 Rat
Cellular Locus
Cytoplasm, Cell membrane, Secreted.
Host
Rabbit
Species Reactivity
Human,Mouse,Rat,Zebrafish
Immunogen
Recombinant protein within Human Insulin degrading enzyme aa 1-106 / 1019.
Isotype
IgG
Conjugation
Non-conjugated
Type
Recombinant Rabbit monoclonal Antibody
Applications
WB, IHC-P
Positive Control
Concentration
1 mg/mL
Dilution
WB: 1:1,000-1:2,000 ;IHC-P: 1:50-1:200
Purity
Protein A affinity purified.
Form
Liquid
Buffer
1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Molecular Weight
118 kDa
Storage Conditions
Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Recombinant Antibody
Yes
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