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FOXO4 Recombinant Rabbit Monoclonal Antibody [JJ09-11]

Transcription factor involved in the regulation of the insulin signaling pathway. Binds to insulin-response elements (IREs) and can activate transcription of IGFBP1. Down-regulates expression of HIF1A and suppresses hypoxia-induced transcriptional activation of HIF1A-modulated genes. Also involved in negative regulation of the cell cycle. Involved in increased proteasome activity in embryonic stem cells (ESCs) by activating expression of PSMD11 in ESCs, leading to enhanced assembly of the 26S proteasome, followed by higher proteasome activity.

Product Specifications

Product Name Alternative

AFX antibody AFX1 antibody Afxh antibody ALL1-fused gene from X chromosome antibody Fork head domain transcription factor AFX1 antibody Forkhead box O4 antibody Forkhead box protein O4 antibody FOXO 4 antibody Foxo4 antibody FOXO4_HUMAN antibody MGC117660 antibody MGC120490 antibody Mixed lineage leukemia, translocated to, 7 antibody MLLT7 antibody Myeloid/lymphoid or mixed lineage leukemia (trithorax homolog, Drosophila); translocated to, 7 antibody Myeloid/lymphoid or mixed lineage leukemia, translocated to, 7 antibody RGD1561201 antibody

Abbreviation

FOXO4

Swiss Prot

P98177 Human, Q9WVH3 Mouse

Cellular Locus

Nucleus, Cytoplasm.

Host

Rabbit

Species Reactivity

Human,Mouse,Rat

Immunogen

Recombinant protein within Human FOXO4 aa 456-505 / 505.

Isotype

IgG

Conjugation

Non-conjugated

Type

Recombinant Rabbit monoclonal Antibody

Applications

WB, IF-Tissue, IHC-P, FC, IP

Positive Control

293T, Hela, HepG2, human placenta tissue, 293.

Concentration

1 mg/mL

Dilution

WB: 1:500 ;IF-Tissue: 1:50-1:200 ;IHC-P: 1:50-1:200 ;FC: 1:1,000 ;IP: Use at an assay dependent concentration.

Purity

Protein A affinity purified.

Form

Liquid

Buffer

1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Molecular Weight

Predicted band size: 54 kDa

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Recombinant Antibody

Yes

CAS Number

9000-83-3

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