HNF-4-alpha Recombinant Rabbit Monoclonal Antibody [SN72-03]
HNF-4 alpha is a transcription factor that binds DNA as a homodimer. HNF-4 alpha is important in liver, kidney, and intestinal development. It has also been intensely studied as one of a variety of genes responsible for diabetes mellitus. HNF-4 alpha has been shown in knock out mice to be essential for the morphogenic and functional differentiation of hepatocytes. HNF-4 alpha is a dominant regulator of epithelial phenotypes able to drive the mesenchymal-to-epithelial transition when expressed in fibroblasts.
Product Specifications
CAS Number
9000-83-3
Product Name Alternative
Abbreviation
HNF-4-alpha, TCF-14, HNF4A
Swiss Prot
P41235 Human, P49698 Mouse, P22449 Rat
Cellular Locus
Nucleus.
Host
Rabbit
Species Reactivity
Human,Mouse,Rat
Immunogen
Synthetic peptide within Human HNF-4-alpha aa 21-70 / 474.
Isotype
IgG
Conjugation
Non-conjugated
Type
Recombinant Rabbit monoclonal Antibody
Applications
WB, IF-Cell, IHC-P, FC
Positive Control
Concentration
1 mg/mL
Dilution
WB: 1:500-1:2,000 ;IF-Cell: 1:100 ;IHC-P: 1:200-1:3,000 ;FC: 1:1,000
Purity
Protein A affinity purified.
Form
Liquid
Buffer
1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Molecular Weight
Predicted band size: 53 kDa
Storage Conditions
Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Recombinant Antibody
Yes
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