SHP2 Recombinant Rabbit Monoclonal Antibody [SN72-02]
Acts downstream of various receptor and cytoplasmic protein tyrosine kinases to participate in the signal transduction from the cell surface to the nucleus .Positively regulates MAPK signal transduction pathway.Dephosphorylates GAB1, ARHGAP35 and EGFR.Dephosphorylates ROCK2 at 'Tyr-722' resulting in stimulation of its RhoA binding activity.Dephosphorylates CDC73.Dephosphorylates SOX9 on tyrosine residues, leading to inactivate SOX9 and promote ossification.
Product Specifications
CAS Number
9000-83-3
Product Name Alternative
Abbreviation
PTP-1D, PTP-2C, SHP-2, Shp2, PTPN11
Swiss Prot
Q06124 Human, P35235 Mouse, P41499 Rat
Cellular Locus
Cytoplasm, Nucleus.
Host
Rabbit
Species Reactivity
Human,Mouse,Rat
Immunogen
Synthetic peptide within N-terminal human SHP2.
Isotype
IgG
Conjugation
Non-conjugated
Type
Recombinant Rabbit monoclonal Antibody
Applications
WB, IP, IHC-P
Positive Control
Concentration
1 mg/mL
Dilution
WB: 1:1,000-1:5,000 ;IP: Use at an assay dependent concentration. ;IHC-P: 1:500
Purity
Protein A affinity purified.
Form
Liquid
Buffer
1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Molecular Weight
Predicted band size: 68 kDa
Storage Conditions
Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Recombinant Antibody
Yes
Frequently Asked Questions
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