IKK alpha Recombinant Rabbit Monoclonal Antibody [SN06-99]

Inhibitor of nuclear factor kappa-B kinase subunit alpha (IKK-α) also known as IKK1 or conserved helix-loop-helix ubiquitous kinase (CHUK) is a protein kinase that in humans is encoded by the CHUK gene. IKK-α is part of the IκB kinase complex that plays an important role in regulating the NF-κB transcription factor. However, IKK-α has many additional cellular targets, and is thought to function independently of the NF-κB pathway to regulate epidermal differentiation. IKK-α is a member of the serine/threonine protein kinase family and forms a complex in the cell with IKK-β and NEMO. IKK-α has been shown to function in epidermal differentiation independently of the NF-κB pathway. The zebrafish homolog of IKK-α has also been shown to play a role in the differentiation of the embryonic epithelium. IκB kinase α (IKKα) is a regulator of keratinocyte terminal differentiation and proliferation and plays a role in skin cancer.

Product Specifications

CAS Number

9000-83-3

Product Name Alternative

chuk antibody CHUK1 antibody Conserved Helix Loop Helix Ubiquitous Kinase antibody Conserved helix loop ubiquitous kinase antibody Conserved helix-loop-helix ubiquitous kinase antibody I Kappa B Kinase 1 antibody I Kappa B Kinase Alpha antibody I-kappa-B kinase 1 antibody I-kappa-B kinase alpha antibody IkappaB kinase antibody IkB kinase alpha subunit antibody IkBKA antibody IKK 1 antibody IKK A antibody IKK a kinase antibody IKK-A antibody IKK-alpha antibody IKK1 antibody IKKA antibody IKKA_HUMAN antibody Inhibitor Of Kappa Light Polypeptide Gene Enhancer In B Cells antibody Inhibitor Of Nuclear Factor Kappa B Kinase Alpha Subunit antibody Inhibitor of nuclear factor kappa-B kinase subunit alpha antibody NFKBIKA antibody Nuclear Factor Kappa B Inhibitor Kinase Alpha antibody Nuclear factor NF kappa B inhibitor kinase alpha antibody Nuclear factor NF-kappa-B inhibitor kinase alpha antibody Nuclear factor NFkappaB inhibitor kinase alpha antibody Nuclear Factor Of Kappa Light Chain Gene Enhancer In B Cells Inhibitor antibody TCF-16 antibody TCF16 antibody Transcription factor 16 antibody

Abbreviation

I-kappa-B kinase alpha, IKK-A, IKK-alpha, IkBKA, IkappaB kinase, IKK1, NFKBIKA, TCF-16, CHUK

Swiss Prot

O15111 Human, Q60680 Mouse,

Cellular Locus

Cytoplasm, Nucleus.

Host

Rabbit

Species Reactivity

Human,Mouse,Rat

Immunogen

Synthetic peptide within N-terminal human IKK alpha.

Isotype

IgG

Conjugation

Non-conjugated

Type

Recombinant Rabbit monoclonal Antibody

Applications

WB, IHC-P, IP, FC

Positive Control

HeLa cell lysate, HCT 116 cell lysate, SK-OV-3 cell lysate, NIH/3T3 cell lysate, PC-12 cell lysate, Mouse kidney tissue lysate, Rat kidney tissue lysate, rat kidney tissue, HeLa.