Ku80 Recombinant Rabbit Monoclonal Antibody [SC06-14]

The Ku protein is localized in the nucleus and is composed of subunits referred to as Ku-70 (p70) and Ku-86 (p86) which is also known by the synonym Ku-80 or (p80). Ku was first described as an autoantigen to which antibodies were produced in a patient with scleroderma polymyositis overlap syndrome, and was later found in the sera of patients with other rheumatic diseases. Both subunits of the Ku protein have been cloned, and a number of functions have been proposed for Ku, including cell signaling, DNA replication and transcriptional activation. Ku is involved in Pol II-directed transcription by virtue of its DNA binding activity, serving as the regulatory component of the DNA-associated protein kinase that phosphorylates Pol II and transcription factor Sp. Ku proteins also activate transcription from the U1 small nuclear RNA and the human transferrin receptor gene promoters. A Ku-related protein designated the enhancer 1 binding factor (E1BF), composed of two subunits, has been identified as a positive regulator of RNA polymerase I transcription initiation.

Product Specifications

CAS Number

9000-83-3

Product Name Alternative

86 kDa subunit of Ku antigen antibody ATP dependent DNA helicase 2 subunit 2 antibody ATP dependent DNA helicase II 80 kDa subunit antibody ATP dependent DNA helicase II 86 Kd subunit antibody ATP dependent DNA helicase II antibody ATP-dependent DNA helicase 2 subunit 2 antibody ATP-dependent DNA helicase II 80 kDa subunit antibody CTC box binding factor 85 kDa antibody CTC box-binding factor 85 kDa subunit antibody CTC85 antibody CTCBF antibody DNA repair protein XRCC5 antibody KARP 1 antibody KARP1 antibody Ku 80 antibody Ku autoantigen 80kDa antibody Ku80 antibody Ku86 antibody Ku86 autoantigen related protein 1 antibody KUB 2 antibody KUB2 antibody Lupus Ku autoantigen protein p86 antibody NFIV antibody Nuclear factor IV antibody Thyroid lupus autoantigen antibody Thyroid-lupus autoantigen antibody TLAA antibody X ray repair complementing defective repair in Chinese hamster cells 5 (double strand break rejoining) antibody X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining) antibody X-ray repair cross-complementing protein 5 antibody Xray repair complementing defective repair in Chinese hamster cells 5 antibody XRCC 5 antibody XRCC5 antibody XRCC5_HUMAN antibody

Abbreviation

CTC85, CTCBF, TLAA, XRCC5

Swiss Prot

P13010 Human

Cellular Locus

Nucleus, Chromosome.

Host

Rabbit

Species Reactivity

Human,Monkey

Immunogen

Synthetic peptide within Human Ku80 aa 693-732 / 732.

Isotype

IgG

Conjugation

Non-conjugated

Type

Recombinant Rabbit monoclonal Antibody

Applications

WB, IF-Cell, IF-Tissue, IHC-P, IP, FC

Positive Control

HeLa cell lysate, MCF7 cell lysate, A549 cell lysate, COS-1 cell lysate, human colon cancer tissue, Hela, A549, SW480, human kideny tissue, human colon cancer tissue, human tonsil tissue, human breast carcinoma tissue, MCF7.