Phospho-ATF2 (T71) Recombinant Rabbit Monoclonal Antibody [SC05-90]

Eukaryotic gene transcription is regulated by sequence-specific transcription factors which bind modular cis-acting promotor and enhancer elements. The ATF/CREB transcription factor family binds the palindromic cAMP response element (CRE) octanucleotide TGACGTCA. The ATF/CREB family includes CREB-1, CREB-2 (also designated ATF-4), ATF-1, ATF-2 and ATF-3. This family of proteins contain highly divergent N-terminal domains, but share a C-terminal leucine zipper for dimerization and DNA binding. ATF-2 forms homodimers and heterodimers with c-Jun to initiate CRE-dependent transcription. Phosphorylation of ATF-2 at Thr 69 and Thr 71 by stress-activated kinases is necessary for transcriptional activation. Myc also induces phosphorylation of ATF-2 at Thr 69 and Thr 71 to prolong the half-life of ATF-2. ATF-2 also functions as a histone acetyltransferase (HAT) by specifically acetylating histones H2B and H4 in vitro. The gene encoding human ATF-2 maps to chromosome 2q31.1.

Product Specifications

CAS Number

9000-83-3

Product Name Alternative

Activating transcription factor 2 antibody Activating transcription factor 2 splice variant ATF2 var2 antibody ATF 2 antibody Atf-2 antibody Atf2 antibody ATF2 protein antibody ATF2_HUMAN antibody cAMP Response Element Binding Protein 2 antibody cAMP response element binding protein CRE BP1 antibody cAMP response element-binding protein CRE-BP1 antibody cAMP responsive element binding protein 2, formerly antibody cAMP-dependent transcription factor ATF-2 antibody cAMP-responsive element-binding protein 2 antibody CRE BP1 antibody CRE-BP antibody CREB 2 antibody CREB-2 antibody CREB2 antibody CREBP1 antibody Cyclic AMP dependent transcription factor ATF 2 antibody Cyclic AMP-dependent transcription factor ATF-2 antibody Cyclic AMP-responsive element-binding protein 2 antibody D130078H02Rik antibody D18875 antibody HB 16 antibody HB16 antibody Histone acetyltransferase ATF2 antibody MGC105211 antibody MGC105222 antibody MGC111558 antibody MGC142504 antibody mXBP antibody MXBP protein antibody Tg (Gzma-Klra1)7Wum antibody TREB 7 antibody TREB7 antibody

Abbreviation

LRP-1, A2MR, APOER, CD91

Swiss Prot

P15336 Human, P16951 Mouse, Q00969 Rat

Cellular Locus

Mitochondrion outer membrane, Nucleus, Cytoplasm.

Host

Rabbit

Species Reactivity

Human,Mouse,Rat

Immunogen

Synthetic phospho-peptide corresponding to residues surrounding Thr71 of Human ATF2 aa 58-94 / 505.

Isotype

IgG

Conjugation

Non-conjugated

Type

Recombinant Rabbit monoclonal Antibody

Applications

WB, IF-Cell, IF-Tissue, IP, IHC-P

Positive Control

Hela, NIH/3T3, SH-SY5Y, rat brain tissue, human prostate tissue, human uterus tissue, mouse colon tissue, human cervix tissue, human skin tissue, human breast tissue, human esophagus tissue, human placenta tissue, mouse large intestine tissue, Hela cells treated with 250ng/mL anisomycin for 30 minutes.