CD11a Recombinant Rabbit Monoclonal Antibody [SC56-01]

Integrins are heterodimers composed of noncovalently associated transmembrane a and b subunits. The 16 a and 8 b subunits heterodimerize to produce more than 20 different receptors. Most integrin receptors bind ligands that are components of the extracellular matrix, including Fibronectin, Collagen and Vitronectin. Certain integrins can also bind to soluble ligands such as Fibrinogen, or to counterreceptors on adjacent cells such as the intracellular adhesion molecules (ICAMs), leading to aggregation of cells. Ligands serve to cross-link or cluster integrins by binding to adjacent integrin receptors; both receptor clustering and ligand occupancy are necessary for the activation of integrin-mediated responses. In addition to mediating cell adhesion and cytoskeletal organization, integrins function as signaling receptors. Signals transduced by integrins play a role in many biological processes, including cell growth, differentiation, migration and apoptosis.

Product Specifications

CAS Number

9000-83-3

Product Name Alternative

Lymphocyte function associated antigen, type 1, alpha subunit antibody Antigen CD11A (p180), lymphocyte function associated antigen 1, alpha polypeptide antibody Antigen CD11A antibody CD 11a antibody CD11 antigen-like family member A antibody CD11a antibody CD11a antigen antibody Integrin Alpha L antibody Integrin alpha-L antibody Integrin gene promoter antibody Integrin, alpha L (antigen CD11A (p180), lymphocyte function associated antigen 1; alpha polypeptide) antibody ITAL_HUMAN antibody Itgal antibody ITGAL protein antibody Leukocyte adhesion glycoprotein LFA 1 alpha chain antibody Leukocyte adhesion glycoprotein LFA-1 alpha chain antibody Leukocyte Adhesion Glycoprotein LFA1 Alpha Chain antibody Leukocyte function associated molecule 1 alpha chain antibody Leukocyte function-associated molecule 1 alpha chain antibody LFA 1 alpha (LFA1A) antibody LFA 1 alpha antibody LFA 1 antibody LFA 1A antibody LFA-1A antibody LFA1A antibody Ly15 antibody Ly21 antibody Lymphocyte function associated antigen 1 antibody Lymphocyte Function Associated Antigen Type 1 alpha antibody lymphocyte function-associated antigen 1, alpha polypeptide antibody p180 antibody

Abbreviation

LFA-1A, ITGAL, CD11A

Swiss Prot

P20701 Human

Cellular Locus

Cell membrane.

Host

Rabbit

Species Reactivity

Human

Immunogen

Synthetic peptide within Human CD11a aa 1,135-1,170 / 1,170.

Isotype

IgG

Conjugation

Non-conjugated

Type

Recombinant Rabbit monoclonal Antibody

Applications

WB, IF-Tissue, IHC-P, IP

Positive Control

THP-1 cell lysate, human colon tissue, human tonsil tissue, human spleen tissue.

Concentration

1 mg/mL

Dilution

WB: 1:2,000-1:5,000 ;IF-Tissue: 1:50-1:200 ;IHC-P: 1:200-1:1,000 ;IP: 1-2μg/sample

Purity

Protein A affinity purified.

Form

Liquid

Buffer

1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Molecular Weight

Predicted band size: 129 kDa

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Recombinant Antibody

Yes

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