PI 3 Kinase p85 beta Recombinant Rabbit Monoclonal Antibody [ST04-77]

Phosphatidylinositol 3-kinase (PI 3-kinase) is composed of p85 and p110 subunits. p85 lacks PI 3-kinase activity and acts as an adapter, coupling p110 to activated protein tyrosine kinase. Two forms of p85 have been described (p85α and p85β), each possessing one SH3 and two SH2 domains. Various p110 isoforms have been identified. p110α and p110β interact with p85α, and p110α has also been shown to interact with p85β in vitro. p110α expression is restricted to white blood cells. It has been shown to bind p85α and p85β, but it apparently does not phosphorylate these subunits. p110α seems to have the capacity to autophosphorylate. p110α does not interact with the p85 subunits. It has been shown to be activated by α and β heterotrimeric G proteins.

Product Specifications

CAS Number

9000-83-3

Product Name Alternative

p85 antibody p85 beta antibody P85B antibody P85B_HUMAN antibody Phosphatidylinositol 3 kinase antibody Phosphatidylinositol 3 kinase regulatory beta subunit antibody Phosphatidylinositol 3 kinase regulatory subunit beta antibody Phosphatidylinositol 3 kinase regulatory subunit polypeptide 2 antibody Phosphatidylinositol 3 kinase, regulatory subunit, polypeptide 2 (p85 beta) antibody Phosphatidylinositol 3-kinase 85 kDa regulatory subunit beta antibody Phosphatidylinositol 3-kinase regulatory subunit beta antibody Phosphoinositide 3 kinase regulatory subunit 2 (beta) antibody Phosphoinositide 3 kinase regulatory subunit 2 antibody Phosphoinositide 3 kinase regulatory subunit polypeptide 2 (p85 beta) antibody Phosphoinositide 3 kinase regulatory subunit polypeptide 2 antibody Phosphoinositide 3 kinase, regulatory subunit 2 (beta) antibody Phosphoinositide 3 kinase, regulatory subunit 2 (p85 beta) antibody PI3 kinase p85 beta subunit antibody PI3 kinase p85 subunit beta antibody PI3-kinase regulatory subunit beta antibody PI3-kinase subunit p85-beta antibody PI3K antibody PI3K regulatory subunit beta antibody PIK3R 2 antibody PIK3R2 antibody PtdIns 3 kinase p85 beta antibody PtdIns-3-kinase regulatory subunit beta antibody PtdIns-3-kinase regulatory subunit p85-beta antibody

Abbreviation

PI3-kinase regulatory subunit beta, PI3K regulatory subunit beta, PtdIns-3-kinase regulatory subunit beta, PI3-kinase subunit p85-beta, PtdIns-3-kinase regulatory subunit p85-beta, PIK3R2

Swiss Prot

O00459 Human, O08908 Mouse, Q63788 Rat

Cellular Locus

Cytosol, nucleus

Host

Rabbit

Species Reactivity

Human,Mouse,Rat

Immunogen

Synthetic peptide within Human PI 3 Kinase p85 beta aa 136-185 / 728.

Isotype

IgG

Conjugation

Non-conjugated

Type

Recombinant Rabbit monoclonal Antibody

Applications

WB, IF-Cell, IF-Tissue, IHC-P, IP, FC

Positive Control

Raji cell lysate, Hela cell lysate, MCF-7 cell lysate, U937 cell lysate, PC-12 cell lysates, Hela, SHG-44, rat testis tissue, rat brain tissue, NIH/3T3 cell lysates.