Aurora A Recombinant Rabbit Monoclonal Antibody [ST46-07]
Aurora A is a member of a family of mitotic serine/threonine kinases. It is implicated with important processes during mitosis and meiosis whose proper function is integral for healthy cell proliferation. Aurora A is activated by one or more phosphorylations and its activity peaks during the G2 phase to M phase transition in the cell cycle. Activation occurs via autophosphorylation, and while 14 sites are subject to this, only the threonine residue at position 295 is required for activity. Though autophosphorylation mediates activation, a number of other proteins influence activation, including the spindle assembly factor TPX2 and p53
Product Specifications
CAS Number
9000-83-3
Product Name Alternative
Abbreviation
ARK-1, Aurora-related kinase 1, hARK1, AURKA
Swiss Prot
O14965 Human, P97477 Mouse, P59241 Rat
Cellular Locus
Cytoplasm, Cytoskeleton, Nucleus, Cell projection, Microtubule.
Host
Rabbit
Species Reactivity
Human,Mouse,Rat
Immunogen
Synthetic peptide within Human Aurora A aa 1-50 / 403.
Isotype
IgG
Conjugation
Non-conjugated
Type
Recombinant Rabbit monoclonal Antibody
Applications
WB, IF-Cell, IHC-P, FC
Positive Control
K562 cell lysates, SKOV-3, Hela, NIH/3T3, rat testis tissue.
Concentration
1 mg/mL
Dilution
WB: 1:500-1:2,000;IF-Cell: 1:50-1:100;IHC-P: 1:100-1:500;FC: 1:50-1:100
Purity
Protein A affinity purified.
Form
Liquid
Buffer
1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Molecular Weight
Predicted band size: 46 kDa
Storage Conditions
Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Recombinant Antibody
Yes
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