Histone H4 (tri methyl K20) Recombinant Rabbit Monoclonal Antibody [ST044-07]
Eukaryotic histones are basic and water soluble nuclear proteins that form hetero-octameric nucleosome particles by wrapping 146 base pairs of DNA in a left-handed super-helical turn sequentially to form chromosomal fibers. Two molecules of each of the four core histones (H2A, H2B, H3 and H4) form the octamer, which is comprised of two H2A-H2B dimers and two H3-H4 dimers, forming two nearly symmetrical halves by tertiary structure. Histones are subject to posttranslational modification by enzymes primarily on their N-terminal tails, but also in their globular domains. Human and mouse Histone H4 are subject to trimethylation at Lys 20, a modification that may be necessary for select DNA transactions or chromatin state transitions.
Product Specifications
CAS Number
9000-83-3
Product Name Alternative
Abbreviation
HIST1H4A H4K20me3
Swiss Prot
P62805 Human, P62806 Mouse, P62804 Rat
Cellular Locus
Nucleus, Chromosome.
Host
Rabbit
Species Reactivity
Human,Mouse,Rat
Immunogen
Synthetic peptide within Human Histone H4 aa 1-50 / 103.
Isotype
IgG
Conjugation
Non-conjugated
Type
Recombinant Rabbit monoclonal Antibody
Applications
WB, IHC-P
Positive Control
Human liver tissue, human kidney tissue, mouse liver tissue, mouse colon tissue, mouse kidney tissue.
Concentration
1 mg/mL
Dilution
WB: 1:1,000 ;IHC-P: 1:50-1:800
Purity
Protein A affinity purified.
Form
Liquid
Buffer
1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Molecular Weight
Predicted band size: 11 kDa
Storage Conditions
Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Recombinant Antibody
Yes
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