Plectin Recombinant Rabbit Monoclonal Antibody [SY29-04]
Plectin is a giant protein found in nearly all mammalian cells which acts as a link between the three main components of the cytoskeleton: actin microfilaments, microtubules and intermediate filaments. Plectin links the cytoskeleton to junctions found in the plasma membrane that structurally connect different cells. By holding these different networks together, plectin plays an important role in maintaining the mechanical integrity and viscoelastic properties of tissues. Plectin binds both Lamin B and vimentin, and this binding is regulated by a variety of protein kinases. Phosphorylation by PKA or PKC results in decreased binding to Lamin B, and phosphorylation by PKA enhances the plectin-vimentin interactions.
Product Specifications
CAS Number
9000-83-3
Product Name Alternative
Abbreviation
PCN, PLTN, HD1, PLEC
Swiss Prot
Q15149 Human, Q9QXS1 Mouse, P30427 Rat
Cellular Locus
Cell junction, Cytoplasm, Cytoskeleton.
Host
Rabbit
Species Reactivity
Human,Mouse,Rat
Immunogen
Recombinant protein within Human Plectin aa 2-101 / 4,684.
Isotype
IgG
Conjugation
Non-conjugated
Type
Recombinant Rabbit monoclonal Antibody
Applications
WB, IHC-P, IP, IF-Tissue, IF-Cell
Positive Control
Human skeletal muscle tissue, mouse skeletal muscle tissue, rat skeletal muscle tissue, HeLa.
Concentration
1 mg/mL
Dilution
WB: 1:1,000 ;IHC-P: 1:200-1:1,000 ;IP: 1-2μg/sample ;IF-Tissue: 1:100-1:200 ;IF-Cell: 1:100
Purity
Protein A affinity purified.
Form
Liquid
Buffer
1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Molecular Weight
Predicted band size: 532 kDa
Storage Conditions
Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Recombinant Antibody
Yes
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