CD20 Recombinant Rabbit Monoclonal Antibody [SY12-01]
CD20 is a leukocyte surface antigen consisting of four transmembrane regions and cytoplasmic N- and C-termini. The cytoplasmic domain of CD20 contains multiple phosphorylation sites, leading to additional isoforms. CD20 is expressed primarily on B cells but has also been detected on both normal and neoplastic T cells. CD20 functions as a calcium-permeable cation channel, and it is known to accelerate the G0 to G1 progression induced by IGF-1. CD20 is activated by the IGF-1 receptor via the alpha subunits of the heterotrimeric G proteins. Activation of CD20 significantly increases DNA synthesis and is thought to involve basic helix-loop-helix leucine zipper transcription factors.
Product Specifications
CAS Number
9000-83-3
Product Name Alternative
Abbreviation
MS4A1
Swiss Prot
P11836 Human
Cellular Locus
Cell membrane.
Host
Rabbit
Species Reactivity
Human,Monkey
Immunogen
Synthetic peptide within Human CD20 aa 248-297 / 297.
Isotype
IgG
Conjugation
Non-conjugated
Type
Recombinant Rabbit monoclonal Antibody
Applications
WB, IHC-P, IF-Tissue, IF-Cell, FC, IP
Positive Control
Raji cell lysate, Ramos cell lysate, Daudi cell lysate, human tonsil tissue, human spleen tissue, B-cell lymphoma tissue, Raji.
Concentration
1 mg/mL
Dilution
WB: 1:1,000-1:5,000 ;IHC-P: 1:200 ;IF-Tissue: 1:50 ;IF-Cell: 1:100 ;FC: 1:1,000 ;IP: 1-2μg/sample
Purity
Protein A affinity purified.
Form
Liquid
Buffer
1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Molecular Weight
Predicted band size: 33 kDa
Storage Conditions
Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Recombinant Antibody
Yes
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