Smad4 Recombinant Rabbit Monoclonal Antibody [SP05-05]

Smad proteins, the mammalian homologs of the Drosophila Mothers against dpp (Mad) have been implicated as downstream effectors of TGFβ/BMP signaling. Smad1 (also designated Madr1 or JV4-1), Smad5 and mammalian Smad8 (also designated Smad9 or MADH6) are effectors of BMP2 and BMP4 function while Smad2 (also designated Madr2 or JV18-1) and Smad3 are involved in TGFβ and activin-mediated growth modulation. Smad4 (also designated DPC4) has been shown to mediate all of the above activities through interaction with various Smad family members. Smad6 and Smad7 regulate the response to activin/TGFβ signaling by interfering with TGFβ-mediated phosphorylation of other Smad family members.

Product Specifications

CAS Number

9000-83-3

Product Name Alternative

(Small) Mothers Against Decapentaplegic antibody Deleted in Pancreatic Carcinoma 4 antibody Deleted in Pancreatic Carcinoma antibody Deleted in pancreatic carcinoma locus 4 antibody Deletion target in pancreatic carcinoma 4 antibody DPC 4 antibody DPC4 antibody hSMAD4 antibody JIP antibody MAD homolog 4 antibody MAD mothers against decapentaplegic Drosophila homolog 4 antibody MAD mothers against decapentaplegic homolog 4 antibody MADH 4 antibody MADH4 antibody Med antibody Medea antibody Mothers against decapentaplegic homolog 4 antibody Mothers against decapentaplegic, Drosophila, homolog of, 4 antibody Mothers against DPP homolog 4 antibody MYHRS antibody OTTHUMP00000163548 antibody SMA- and MAD-related protein 4 antibody SMAD 4 antibody SMAD family member 4 antibody SMAD mothers against DPP homolog 4 antibody SMAD4 antibody SMAD4_HUMAN antibody

Abbreviation

MAD homolog 4, Mothers against DPP homolog 4, SMAD 4, Smad4, hSMAD4, SMAD4

Swiss Prot

Q13485 Human, P97471 Mouse, O70437 Rat

Cellular Locus

Cytoplasm, Nucleus.

Host

Rabbit

Species Reactivity

Human,Mouse,Rat

Immunogen

Synthetic peptide within C-terminal human Smad4.

Isotype

IgG

Conjugation

Non-conjugated

Type

Recombinant Rabbit monoclonal Antibody

Applications

WB, IF-Cell, IF-Tissue, IHC-P, FC

Positive Control

HeLa cell lysate, HCT 116 cell lysate, C6 cell lysate, Neuro-2a cell lysates, HeLa, Neuro-2a, PC-12, human colon tissue, human lung tissue, mouse lung tissue, rat lung tissue.