AIF Recombinant Rabbit Monoclonal Antibody [SZ05-01]

A key event in the apoptotic process is the opening of the mitochondrial permeability transition pore, an event that is regulated by Bcl-2 family proteins, resulting in the release of several proteins from the mitochondrial intermembrane space. Several of these proteins participate in apoptosis, including cytochrome c, procaspases 2, 3, and 9, and AIF (apoptosis-inducing factor). AIF has been shown to cause DNA fragmentation and chromatin condensation and to induce the release of cytochrome c and caspase-9 from mitochondria. Bcl-2 overexpression has been shown to prevent the release of AIF from mitochondria, but not to block its apoptogenic activity.

Product Specifications

CAS Number

9000-83-3

Product Name Alternative

AIFM1 antibody AIFM1_HUMAN antibody Apoptosis inducing factor 1, mitochondrial antibody Apoptosis inducing factor antibody Apoptosis inducing factor, mitochondrion associated, 1 antibody Apoptosis-inducing factor 1 antibody CMTX4 antibody COWCK antibody COXPD6 antibody Harlequin antibody Hq antibody mAIF antibody MGC111425 antibody MGC5706 antibody mitochondrial antibody Neuropathy, axonal motor-sensory, with deafness and mental retardation antibody neuropathy, axonal, motor-sensory with deafness and mental retardation (Cowchock syndrome) antibody PDCD 8 antibody PDCD8 antibody Programmed cell death 8 (apoptosis inducing factor) antibody Programmed cell death 8 antibody Programmed cell death 8 isoform 1 antibody Programmed cell death 8 isoform 2 antibody Programmed cell death 8 isoform 3 antibody Programmed cell death protein 8 antibody Programmed cell death protein 8 mitochondrial antibody Programmed cell death protein 8 mitochondrial precursor antibody Programmed cell death protein 8 mitochondrial precursor antibody Striatal apoptosis inducing factor antibody

Abbreviation

AIFM1

Swiss Prot

O95831 Human, Q9Z0X1 Mouse, Q9JM53 Rat

Cellular Locus

Mitochondrion intermembrane space, Mitochondrion inner membrane, Cytoplasm, Nucleus, Membrane.

Host

Rabbit

Species Reactivity

Human,Mouse,Rat

Immunogen

Synthetic peptide within Human AIF aa 502-551 / 613.

Isotype

IgG

Conjugation

Non-conjugated

Type

Recombinant Rabbit monoclonal Antibody

Applications

WB, IF-Cell, IHC-P, IP, FC

Positive Control

SKOV-3 cell lysate, Daudi cell lysate, MCF-7 cell lysate, Hela cell lysate, C2C12 cell lysate, NIH/3T3 cell lysate, C6 cell lysate, Mouse liver tissue lysate, Rat liver tissue lysate, Mouse kidney tissue lysate, Rat kidney tissue lysate, MCF-7, SKOV-3, C2C12, human liver tissue, human kidney tissue, mouse liver tissue, mouse heart tissue, rat liver tissue, rat kidney tissue, HeLa.