Alas1 Recombinant Rabbit Monoclonal Antibody [SA70-04]
Delta-aminolevulinate synthase 1 also known as ALAS1 is a protein that in humans is encoded by the ALAS1 gene. ALAS1 is an aminolevulinic acid synthase. Delta-aminolevulinate synthase catalyzes the condensation of glycine with succinyl-CoA to form delta-aminolevulinic acid. This nuclear-encoded mitochondrial enzyme is the first and rate-limiting enzyme in the mammalian heme biosynthetic pathway. There are 2 tissue-specific isozymes: a housekeeping enzyme encoded by the ALAS1 gene and an erythroid tissue-specific enzyme encoded by ALAS2. Mice lacking this gene exhibit embryonic embryonic lethality, indicating that ALAS is essential for early embryogenesis.
Product Specifications
CAS Number
9000-83-3
Product Name Alternative
Abbreviation
ALAS-H
Swiss Prot
P13196 Human
Cellular Locus
Mitochondrion matrix
Host
Rabbit
Species Reactivity
Human
Immunogen
Recombinant protein within Human Alas1 aa 510-640 / 640.
Isotype
IgG
Conjugation
Non-conjugated
Type
Recombinant Rabbit monoclonal Antibody
Applications
WB, IF-Cell, IF-Tissue
Positive Control
JAR cell lysate, HUVEC cell lysate, Hela cell lysate, Hela, HepG2, MCF-7.
Concentration
1 mg/mL
Dilution
WB: 1:500-1:1,000 ;IF-Cell: 1:50 ;IF-Tissue: 1:50
Purity
Protein A affinity purified.
Form
Liquid
Buffer
1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Molecular Weight
Predicted band size: 71 kDa
Storage Conditions
Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Recombinant Antibody
Yes
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