Histone H3 (mono methyl K18) Recombinant Rabbit Monoclonal Antibody [SA42-07]
Histone H3 is one of the five main histones involved in the structure of chromatin in eukaryotic cells. Featuring a main globular domain and a long N-terminal tail, H3 is involved with the structure of the nucleosomes of the 'beads on a string' structure. Histone proteins are highly post-translationally modified however Histone H3 is the most extensively modified of the five histones. The term "Histone H3" alone is purposely ambiguous in that it does not distinguish between sequence variants or modification state. Histone H3 is an important protein in the emerging field of epigenetics, where its sequence variants and variable modification states are thought to play a role in the dynamic and long term regulation of genes.
Product Specifications
CAS Number
9000-83-3
Product Name Alternative
Abbreviation
Histone H3 H3K18me1
Swiss Prot
P68431 Human, P84243 Human, Q71DI3 Human, Q16695 Human, Q6NXT2 Human, P68433 Mouse, Q6LED0 Rat
Cellular Locus
Nucleus, Chromosome
Host
Rabbit
Species Reactivity
Human,Mouse,Rat
Immunogen
Synthetic peptide within Human Histone H3 aa 1-50 / 136 (mono methyl K18) conjugated to Keyhole Limpet Haemocyanin (KLH).
Isotype
IgG
Conjugation
Non-conjugated
Type
Recombinant Rabbit monoclonal Antibody
Applications
WB, IF-Cell, IF-Tissue, IHC-P
Positive Control
HepG2 cell lysates, mouse testis tissue lysates, HepG2, PC-3M, human colon tissue, mouse testis tissue, mouse kidney tissue.
Concentration
1 mg/mL
Dilution
WB: 1:500-1:5,000 ;IF-Cell: 1:50 ;IF-Tissue: 1:50 ;IHC-P: 1:50-1:1,000
Purity
Protein A affinity purified.
Form
Liquid
Buffer
1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Molecular Weight
Predicted band size: 15 kDa
Storage Conditions
Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Recombinant Antibody
Yes
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