LRP1 Recombinant Rabbit Monoclonal Antibody [SA0290]

LRP1 is a member of the LDLR family and ubiquitously expressed in multiple tissues, though it is most abundant in vascular smooth muscle cells (SMCs), hepatocytes, and neurons. LRP1 plays a key role in intracellular signaling and endocytosis, which thus implicate it in many cellular and biological processes, including lipid and lipoprotein metabolism, protease degradation, platelet derived growth factor receptor regulation, integrin maturation and recycling, regulation of vascular tone, regulation of blood brain barrier permeability, cell growth, cell migration, inflammation, and apoptosis, as well as diseases such as neurodegenerative diseases, atherosclerosis, and cancer. The LRP1 gene encodes a 600 kDa precursor protein that is processed by furin in the trans-Golgi complex, resulting in a 515 kDa alpha-chain and an 85 kDa beta-chain associated noncovalently.

Product Specifications

CAS Number

9000-83-3

Product Name Alternative

A2MR antibody Alpha 2 macroglobulin receptor antibody alpha 2MR antibody Alpha-2-macroglobulin receptor antibody APOER antibody Apolipoprotein E receptor antibody APR antibody CD 91 antibody CD91 antibody CD91 antigen antibody IGFBP3R antibody LDL receptor related protein 1 antibody Low density lipoprotein receptor related protein 1 antibody Low density lipoprotein related protein 1 antibody Low-density lipoprotein receptor-related protein 1 intracellular domain antibody LRP 1 antibody LRP 515 antibody LRP 85 antibody LRP antibody LRP ICD antibody LRP-1 antibody LRP-515 antibody LRP-85 antibody Lrp1 antibody LRP1 protein antibody LRP1_HUMAN antibody LRP1A antibody LRP515 antibody LRP85 antibody LRPICD antibody MGC88725 antibody Prolow density lipoprotein receptor related protein 1 antibody TbetaR V/LRP 1/IGFBP 3 receptor antibody TbetaRV/LRP1/IGFBP3 receptor antibody TGFBR 5 antibody TGFBR5 antibody Type V tgf beta receptor antibody Low-density lipoprotein receptor-related protein 1 85 kDa subunit

Abbreviation

LRP-1, A2MR, APOER, CD91

Swiss Prot

Q07954 Human, Q91ZX7 Mouse, G3V928 Rat

Cellular Locus

Cytoplasm, Nucleus, Membrane.

Host

Rabbit

Species Reactivity

Human,Mouse,Rat

Immunogen

Synthetic peptide within Human LRP1 aa 4,471-4,520 / 4,544.

Isotype

IgG

Conjugation

Non-conjugated

Type

Recombinant Rabbit monoclonal Antibody

Applications

WB, IF-Tissue, IHC-P, IP, IHC-Fr

Positive Control

Mouse liver tissue lysate, Human lung tissue lysate, Rat liver tissue lysate, Rat lung tissue lysate, Mouse lung tissue lysate, Human liver tissue lysate, mouse brain tissue, rat brain tissue, rat liver tissue, human lung tissue, human liver tissue, mouse liver tissue.