LRP1 Recombinant Rabbit Monoclonal Antibody [SA0290]
LRP1 is a member of the LDLR family and ubiquitously expressed in multiple tissues, though it is most abundant in vascular smooth muscle cells (SMCs), hepatocytes, and neurons. LRP1 plays a key role in intracellular signaling and endocytosis, which thus implicate it in many cellular and biological processes, including lipid and lipoprotein metabolism, protease degradation, platelet derived growth factor receptor regulation, integrin maturation and recycling, regulation of vascular tone, regulation of blood brain barrier permeability, cell growth, cell migration, inflammation, and apoptosis, as well as diseases such as neurodegenerative diseases, atherosclerosis, and cancer. The LRP1 gene encodes a 600 kDa precursor protein that is processed by furin in the trans-Golgi complex, resulting in a 515 kDa alpha-chain and an 85 kDa beta-chain associated noncovalently.
Product Specifications
CAS Number
9000-83-3
Product Name Alternative
Abbreviation
LRP-1, A2MR, APOER, CD91
Swiss Prot
Q07954 Human, Q91ZX7 Mouse, G3V928 Rat
Cellular Locus
Cytoplasm, Nucleus, Membrane.
Host
Rabbit
Species Reactivity
Human,Mouse,Rat
Immunogen
Synthetic peptide within Human LRP1 aa 4,471-4,520 / 4,544.
Isotype
IgG
Conjugation
Non-conjugated
Type
Recombinant Rabbit monoclonal Antibody
Applications
WB, IF-Tissue, IHC-P, IP, IHC-Fr
Positive Control
Concentration
1 mg/mL
Dilution
WB: 1:1,000-1:5,000 ;IF-Tissue: 1:50 ;IHC-P: 1:200-1:2,000 ;IP: 1-2μg/sample ;IHC-Fr: 1:100
Purity
Protein A affinity purified.
Form
Liquid
Buffer
1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Molecular Weight
Predicted band size: 505 kDa
Storage Conditions
Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Recombinant Antibody
Yes
Frequently Asked Questions
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