COPS8 Rabbit Polyclonal Antibody
Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively.
Product Specifications
CAS Number
9007-83-4
Product Name Alternative
Abbreviation
COP9 signalosome complex subunit 8,SGN8,Signalosome subunit 8,COP9 homolog hCOP9 JAB1-containing signalosome subunit 8
Swiss Prot
Q99627 Human, Q8VBV7 Mouse, Q6P4Z9 Rat
Cellular Locus
Cytoplasm, Nucleus, Signalosome.
Host
Rabbit
Species Reactivity
Human,Mouse,Rat
Immunogen
Recombinant protein within human COPS8 aa 1-300.
Isotype
IgG
Conjugation
Non-conjugated
Type
Rabbit polyclonal Antibody
Applications
WB, IHC-P
Positive Control
SHSY5Y cell lysate, HL-60 cell lysate, rat brain tissue, rat cerebellum tissue, human liver tissue, human liver carcinoma tissue, mouse brain tissue.
Concentration
1 mg/mL
Dilution
WB:1:500-1:1,000;IHC-P: 1:100-1:500
Purity
Protein A affinity purified.
Form
Liquid
Buffer
1*TBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
Molecular Weight
Predicted band size: 23 kDa.
Storage Conditions
Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
Recombinant Antibody
No
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