Optineurin Rabbit Polyclonal Antibody
This gene encodes the coiled-coil containing protein optineurin. Optineurin may play a role in normal-tension glaucoma and adult-onset primary open angle glaucoma. Optineurin interacts with adenovirus E3-14.7K protein and may utilize tumor necrosis factor-alpha or Fas-ligand pathways to mediate apoptosis, inflammation or vasoconstriction. Optineurin may also function in cellular morphogenesis and membrane trafficking, vesicle trafficking, and transcription activation through its interactions with the RAB8, huntingtin, and transcription factor IIIA proteins. Alternative splicing results in multiple transcript variants encoding the same protein.
Product Specifications
CAS Number
9007-83-4
Product Name Alternative
Abbreviation
OPTN
Swiss Prot
Q96CV9 Human
Cellular Locus
Golgi apparatus, trans-Golgi network, Recycling endosome, perinuclear region, autophagosome, Cytoplasmic vesicle.
Host
Rabbit
Species Reactivity
Human
Immunogen
Synthetic peptide within human optineurin aa 1-40.
Isotype
IgG
Conjugation
Non-conjugated
Type
Rabbit polyclonal Antibody
Applications
WB, FC
Positive Control
A431 cell lysates, human liver tissue, human kidney tissue, human placenta tissue, MCF-7.
Concentration
1 mg/mL
Dilution
WB:1:500-1:1,000 ;FC:1:50-1:100
Purity
Immunogen affinity purified.
Form
Liquid
Buffer
1*TBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
Molecular Weight
66 kDa
Storage Conditions
Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
Recombinant Antibody
No
Frequently Asked Questions
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