CEACAM6 Rabbit Polyclonal Antibody
Cell surface glycoprotein that plays a role in cell adhesion and tumor progression . Intercellular adhesion occurs in a calcium- and fibronectin-independent manner. Mediates homophilic and heterophilic cell adhesion with other carcinoembryonic antigen-related cell adhesion molecules, such as CEACAM5 and CEACAM8 . Heterophilic interaction with CEACAM8 occurs in activated neutrophils . Plays a role in neutrophil adhesion to cytokine-activated endothelial cells . Plays a role as an oncogene by promoting tumor progression; positively regulates cell migration, cell adhesion to endothelial cells and cell invasion . Also involved in the metastatic cascade process by inducing gain resistance to anoikis of pancreatic adenocarcinoma and colorectal carcinoma cells .
Product Specifications
CAS Number
9007-83-4
Product Name Alternative
Abbreviation
Carcinoembryonic antigen-related cell adhesion molecule 6,Non-specific crossreacting antigen Normal cross-reacting antigen,CD66c,CEACAM6
Swiss Prot
P40199 Human
Cellular Locus
Cell membrane, Membrane.
Host
Rabbit
Species Reactivity
Human,Mouse,Rat
Immunogen
Recombinant protein within Human CEACAM6 aa 49-224 / 344.
Isotype
IgG
Conjugation
Non-conjugated
Type
Rabbit polyclonal Antibody
Applications
WB, IHC-P, IF-Cell, FC
Positive Control
Concentration
1 mg/mL
Dilution
WB: 1:500-1:1,000;IHC-P: 1:50-1:200;IF-Cell: 1:50-1:200;FC: 1:50-1:100
Purity
Immunogen affinity purified.
Form
Liquid
Buffer
1*PBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
Molecular Weight
Predicted band size: 37 kDa.
Storage Conditions
Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
Recombinant Antibody
No
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