YARS2 Rabbit Polyclonal Antibody
Catalyzes the attachment of tyrosine to tRNA (Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA (Tyr). Defects in YARS2 are the cause of myopathy with lactic acidosis and sideroblastic anemia type 2 (MLASA2) [MIM:613561]. MLASA2 is a rare oxidative phosphorylation disorder specific to skeletal muscle and bone marrow. Affected individuals manifest sideroblastic anemia, progressive lethargy, muscle weakness, and exercise intolerance associated with persistent lactic acidemia.
Product Specifications
CAS Number
9007-83-4
Product Name Alternative
Abbreviation
yars2
Swiss Prot
F1Q4R5 Zebrafish
Cellular Locus
Cytosol. Mitochondrion.
Host
Rabbit
Species Reactivity
Zebrafish
Immunogen
Recombinant protein within zebrafish YARS2 aa 251-474 / 474.
Isotype
IgG
Conjugation
Non-conjugated
Type
Rabbit polyclonal Antibody
Applications
IF-Tissue, IHC-P
Positive Control
Zebrafish.
Concentration
1 mg/mL
Dilution
IF-Tissue:1:50-1:200;IHC-P:1:50-1:200
Purity
Immunogen affinity purified.
Form
Liquid
Buffer
1*PBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
Molecular Weight
53 kDa
Storage Conditions
Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
Recombinant Antibody
No
Frequently Asked Questions
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