SPATA13 Rabbit Polyclonal Antibody
Acts as guanine nucleotide exchange factor (GEF) for RHOA, RAC1 and CDC42 GTPases. Regulates cell migration and adhesion assembly and disassembly through a RAC1, PI3K, RHOA and AKT1-dependent mechanism. Increases both RAC1 and CDC42 activity, but decreases the amount of active RHOA. Required for MMP9 up-regulation via the JNK signaling pathway in colorectal tumor cells. Involved in tumor angiogenesis and may play a role in intestinal adenoma formation and tumor progression.
Product Specifications
CAS Number
9007-83-4
Product Name Alternative
Abbreviation
Spermatogenesis-associated protein 13 APC-stimulated guanine nucleotide exchange factor 2 SPATA13 Asef2
Swiss Prot
Q96N96 Human, Q5DU57 Mouse
Cellular Locus
Cell membrane, Cell projection, Cytoplasm, Membrane.
Host
Rabbit
Species Reactivity
Human,Rat,Mouse
Immunogen
Recombinant protein within Human SPATA13 aa 423-572 / 652.
Isotype
IgG
Conjugation
Non-conjugated
Type
Rabbit polyclonal Antibody
Applications
WB, IHC-P, FC
Positive Control
Rat kidney tissue lysates, rat testis tissue, human colon cancer tissue, human kidney tissue, SHSY5Y.
Concentration
1 mg/mL
Dilution
WB: 1:500 ;IHC-P: 1:50-1:200 ;FC: 1:50-1:100
Purity
Immunogen affinity purified.
Form
Liquid
Buffer
1*PBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
Molecular Weight
Predicted band size: 75 kDa
Storage Conditions
Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
Recombinant Antibody
No
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