MDM2 Rabbit Polyclonal Antibody

This gene encodes a nuclear-localized E3 ubiquitin ligase. The encoded protein can promote tumor formation by targeting tumor suppressor proteins, such as p53, for proteasomal degradation. This gene is itself transcriptionally-regulated by p53. Overexpression or amplification of this locus is detected in a variety of different cancers. There is a pseudogene for this gene on chromosome 2. Alternative splicing results in a multitude of transcript variants, many of which may be expressed only in tumor cells.

Product Specifications

CAS Number

9007-83-4

Product Name Alternative

ACTFS antibody Double minute 2 protein antibody E3 ubiquitin-protein ligase Mdm2 antibody Hdm 2 antibody Hdm2 antibody HDMX antibody MDM 2 antibody MDM2 antibody MDM2 oncogene E3 ubiquitin protein ligase antibody Mdm2 p53 E3 ubiquitin protein ligase homolog antibody Mdm2 transformed 3T3 cell double minute 2 p53 binding protein (mouse) binding protein 104kDa antibody MDM2_HUMAN antibody MDM2BP antibody Mouse Double Minute 2 antibody MTBP antibody Murine Double Minute Chromosome 2 antibody Oncoprotein Mdm2 antibody p53 Binding Protein Mdm2 antibody p53-binding protein Mdm2 antibody Ubiquitin protein ligase E3 Mdm2 antibody Ubiquitin protein ligase E3 Mdm2 antibody

Abbreviation

MDM2

Swiss Prot

Q00987 Human

Cellular Locus

Nucleoplasm, nucleolus, cytoplasm.

Host

Rabbit

Species Reactivity

Human

Immunogen

Synthetic peptide within Human MDM2 aa 1-50 / 491.

Isotype

IgG

Conjugation

Non-conjugated

Type

Rabbit polyclonal Antibody

Applications

WB, IF-Cell, IHC-P, FC

Positive Control

Human lung tissue lysate, Daudi cell lysate, HepG2, JAR, MCF-7, human thyroid tissue, human skin tissue, human breast carcinoma tissue, human small intestine tissue, human pancreas tissue, Daudi.