CDK4/6-IN-18
CDK4/6-IN-18 (Example 2BrIC) is a selective CDK4/6 inhibitor. CDK4/6-IN-18 inhibits ionizing radiation (IR) -induced DNA damage in cells[1].
Product Specifications
CAS Number
[546102-60-7]
UNSPSC
12352005
Hazard Statement
H302-H315-H319-H335
Target
CDK
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/cdk4-6-in-18.html
Solubility
10 mM in DMSO
Smiles
O=C1NC(C2=C1C3=C(C4=C2C5=C(N4)C=CC=C5)NC6=C3C=CC(Br)=C6)=O
Molecular Formula
C20H10BrN3O2
Molecular Weight
404.22
Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362-P403+P233-P405-P501
References & Citations
[1]Norman E. Sharpless, et al. Hematopoietic protection against ionizing radiation using selective cyclin-dependent kinase 4/6 inhibitors. Patent. WO2010051127 A2.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
CDK4; CDK6
Available Sizes
Curated Selection
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