TRADD Rabbit Polyclonal Antibody
Tumor necrosis factor receptor type 1-associated DEATH domain protein is a protein that in humans is encoded by the TRADD gene. The nuclear form acts as a tumor suppressor by preventing ubiquitination and degradation of isoform p19ARF/ARF of CDKN2A by TRIP12: acts by interacting with TRIP12, leading to disrupt interaction between TRIP12 and isoform p19ARF/ARF of CDKN2A (By similarity). Adapter molecule for TNFRSF1A/TNFR1 that specifically associates with the cytoplasmic domain of activated TNFRSF1A/TNFR1 mediating its interaction with FADD. Overexpression of TRADD leads to two major TNF-induced responses, apoptosis and activation of NF-kappa-B.
Product Specifications
CAS Number
9007-83-4
Product Name Alternative
Abbreviation
TNFR1-associated DEATH domain protein, TRADD
Swiss Prot
Q15628 Human, Q3U0V2 Mouse, D3ZZC5 Rat
Cellular Locus
Cytoplasm. Cytoskeleton. Nucleus.
Host
Rabbit
Species Reactivity
Human,Mouse,Rat
Immunogen
Recombinant protein within Human TRADD aa 109-312 / 312.
Isotype
IgG
Conjugation
Non-conjugated
Type
Rabbit polyclonal Antibody
Applications
WB, IF-Cell, IHC-P
Positive Control
Mouse spleen tissue lysates, rat uterus tissue, human kidney tissue, rat brain tissue, mouse testis tissue, human breast tissue, SH-SY5Y, SiHa.
Concentration
1 mg/mL
Dilution
WB:1:500-1:1,000 ;IF-Cell:1:50-1:200 ;IHC-P:1:50-1:200
Purity
Immunogen affinity purified.
Form
Liquid
Buffer
1*PBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
Molecular Weight
Predicted band size: 34 kDa
Storage Conditions
Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
Recombinant Antibody
No
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