DFNA5 / GSDME Rabbit Polyclonal Antibody
Plays a role in the TP53-regulated cellular response to DNA damage probably by cooperating with TP53. Gasdermin-E, N-terminal: Switches CASP3-mediated apoptosis induced by TNF or danger signals, such as chemotherapy drugs, to pyroptosis. Produced by the cleavage of GSDME by CASP3, perforates cell membrane and thereby induces pyroptosis. After cleavage, moves to the plasma membrane where it strongly binds to inner leaflet lipids, bisphosphorylated phosphatidylinositols, such as phosphatidylinositol (4,5)-bisphosphate. Mediates secondary necrosis downstream of the mitochondrial apoptotic pathway and CASP3 activation as well as in response to viral agents. Exhibits bactericidal activity.
Product Specifications
CAS Number
9007-83-4
Product Name Alternative
Abbreviation
ICERE-1, GSDME-NT, GSDME-CT, GSDME, DFNA5, ICERE1
Swiss Prot
O60443 Human
Cellular Locus
Cell membrane, Cytoplasm, cytosol.
Host
Rabbit
Species Reactivity
Human
Immunogen
Recombinant protein within Human DFNA5 / GSDME aa 1-220 / 496.
Isotype
IgG
Conjugation
Non-conjugated
Type
Rabbit polyclonal Antibody
Applications
WB, IHC-P, FC
Positive Control
Hela cell lysates, SiHa cell lysates, rat testis tissue, human thyroid gland tissue, human breast tissue, mouse small intestine tissue.
Concentration
1 mg/mL
Dilution
WB:1:500-1:1,000 ;IHC-P:1:50-1:200 ;FC:1:50-1:100
Purity
Immunogen affinity purified.
Form
Liquid
Buffer
1*PBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
Molecular Weight
Predicted band size: 55 kDa
Storage Conditions
Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
Recombinant Antibody
No
Frequently Asked Questions
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