RYR1 Rabbit Polyclonal Antibody
Calcium channel that mediates the release of Ca2+ from the sarcoplasmic reticulum into the cytoplasm and thereby plays a key role in triggering muscle contraction following depolarization of T-tubules. Repeated very high-level exercise increases the open probability of the channel and leads to Ca2+ leaking into the cytoplasm. Can also mediate the release of Ca2+ from intracellular stores in neurons, and may thereby promote prolonged Ca2+ signaling in the brain. Required for normal embryonic development of muscle fibers and skeletal muscle. Required for normal heart morphogenesis, skin development and ossification during embryogenesis.
Product Specifications
CAS Number
9007-83-4
Product Name Alternative
Abbreviation
RYR-1, RyR1, RYR1, RYDR
Swiss Prot
P21817 Human, E9PZQ0 Mouse, F1LMY4 Rat
Cellular Locus
Sarcoplasmic reticulum membrane.
Host
Rabbit
Species Reactivity
Human,Mouse
Immunogen
Synthetic peptide within Human RYR1 aa 1,354-1,403 / 5,038.
Isotype
IgG
Conjugation
Non-conjugated
Type
Rabbit polyclonal Antibody
Applications
Dot Blot, IHC-P, FC
Positive Control
Human fetal skeletal muscle tissue, mouse cerebellum tissue, mouse skeletal muscle tissue, rat skeletal muscle tissue, SiHa.
Concentration
1 mg/mL
Dilution
Dot Blot: 1:500-1:1,000 ;IHC-P: 1:50-1:200 ;FC: 1:50-1:100
Purity
Immunogen affinity purified.
Form
Liquid
Buffer
1*PBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
Molecular Weight
Predicted band size: 565 kDa
Storage Conditions
Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
Recombinant Antibody
No
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