Bcl-2 Rabbit Polyclonal Antibody
Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1). May attenuate inflammation by impairing NLRP1-inflammasome activation, hence CASP1 activation and IL1B release.
Product Specifications
CAS Number
9007-83-4
Product Name Alternative
Abbreviation
BCL2
Swiss Prot
P10415 Human, P10417 Mouse
Cellular Locus
Mitochondrion outer membrane, Nucleus membrane, Endoplasmic reticulum membrane, Cytoplasm.
Host
Rabbit
Species Reactivity
Human,Mouse
Immunogen
Synthetic peptide within human BCL-2 20-100 aa.
Isotype
IgG
Conjugation
Non-conjugated
Type
Rabbit polyclonal Antibody
Applications
WB, IF-Cell, FC
Positive Control
HL-60, mouse colon tissue lysate, LOVO, MCF-7, SH-SY-5Y.
Concentration
1 mg/mL
Dilution
WB: 1:200-1:500 ;IF-Cell: 1:50-1:200 ;FC: 1:50-1:100
Purity
Immunogen affinity purified.
Form
Liquid
Buffer
1*PBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
Molecular Weight
22/26 kDa
Storage Conditions
Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
Recombinant Antibody
No
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