RUNX2 Rabbit Polyclonal Antibody

The mammalian Runt-related transcription factor (RUNX) family comprises three members, RUNX1 (also designated AML-1, PEBP2αB, CBFA2), RUNX2 (also designated AML-3, PEBP2αA, CBFA1, Osf2) and RUNX3 (also designated AML-2, PEBPαC, CBFA3). RUNX family members are DNA-binding proteins that regulate the expression of genes involved in cellular differentiation and cell cycle progression. RUNX2 is essential for skeletal mineralization in that it stimulates osteoblast differentiation of mesenchymal stem cells, promotes chondrocyte hypertrophy and contributes to endothelial cell migration and vascular invasion of developing bones. Regulating RUNX2 expression may be a useful therapeutic tool for promoting bone formation. Mutations in the C-terminus of RUNX2 are associated with cleidocranial dysplasia syndrome, an autosomal-dominant skeletal dysplasia syndrome that is characterized by widely patent calvarial sutures, clavicular hypoplasia, supernumerary teeth, and short stature.

Product Specifications

CAS Number

9007-83-4

Product Name Alternative

Acute myeloid leukemia 3 protein antibody Alpha subunit 1 antibody AML3 antibody CBF alpha 1 antibody CBF-alpha-1 antibody CBFA1 antibody CCD antibody CCD1 antibody Cleidocranial dysplasia 1 antibody Core binding factor antibody Core binding factor runt domain alpha subunit 1 antibody Core binding factor subunit alpha 1 antibody Core-binding factor subunit alpha-1 antibody MGC120022 antibody MGC120023 antibody Oncogene AML 3 antibody Oncogene AML-3 antibody OSF 2 antibody OSF-2 antibody OSF2 antibody Osteoblast specific transcription factor 2 antibody Osteoblast-specific transcription factor 2 antibody OTTHUMP00000016533 antibody PEA2 alpha A antibody PEA2-alpha A antibody PEA2aA antibody PEBP2 alpha A antibody PEBP2-alpha A antibody PEBP2A1 antibody PEBP2A2 antibody PEBP2aA antibody PEBP2aA1 antibody Polyomavirus enhancer binding protein 2 alpha A subunit antibody Polyomavirus enhancer-binding protein 2 alpha A subunit antibody Runt domain antibody Runt related transcription factor 2 antibody Runt-related transcription factor 2 antibody RUNX2 antibody RUNX2_HUMAN antibody SL3 3 enhancer factor 1 alpha A subunit antibody SL3-3 enhancer factor 1 alpha A subunit antibody SL3/AKV core binding factor alpha A subunit antibody SL3/AKV core-binding factor alpha A subunit antibody

Abbreviation

CBF-alpha-1, OSF-2, PEA2-alpha A, PEBP2-alpha A, RUNX2, AML3, CBFA1, OSF2, PEBP2A

Swiss Prot

Q13950 Human

Cellular Locus

Nucleus.

Host

Rabbit

Species Reactivity

Human

Immunogen

Synthetic peptide of C-terminal human RUNX2.

Isotype

IgG

Conjugation

Non-conjugated

Type

Rabbit polyclonal Antibody

Applications

WB, IHC-P, IF-Cell

Positive Control

HL-60 cell lysate, A431, human tonsil tissue, human colon tissue.

Concentration

1 mg/mL

Dilution

WB: 1:500;IF-Cell: 1:50-1:200;IHC-P: 1:50-1:200

Purity

Immunogen affinity purified.

Form

Liquid

Buffer

1*PBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.

Molecular Weight

Predicted band size: 57 kDa

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.

Recombinant Antibody

Curated Selection

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