TWEAKR Rabbit Polyclonal Antibody
Fn14, the TWEAK receptor, is a recently identified member of the TNF receptor superfamily and is expressed on smooth muscle cells and endothelial cells. It is a weak inducer of apoptosis and promotes angiogenesis. Fn14 is a type 1 membrane protein. It associates with TRAF1 and TRAF2, and may modulate cellular adhesion to matrix proteins. Fn14 is highly expressed in heart, placenta and kidney, and moderately expressed in lung, skeletal muscle and pancreas. It is the smallest member of the TNF receptor (TNFR) superfamily described to date, and signals via recruitment of several different TNFR-associated factors.
Product Specifications
Product Name Alternative
Abbreviation
FGF-inducible 14, TweakR, TNFRSF12A, FN14
Swiss Prot
Q9NP84 Human, Q9CR75 Mouse
Cellular Locus
Membrane.
Host
Rabbit
Species Reactivity
Human,Mouse
Immunogen
Synthetic peptide within Human TWEAKR aa 80-129 / 129.
Isotype
IgG
Conjugation
Non-conjugated
Type
Rabbit polyclonal Antibody
Applications
IF-Cell, IHC-P, FC
Positive Control
MCF-7, SiHa, human colon cancer tissue, human placenta tissue, mouse testis tissue, 293T.
Concentration
1 mg/mL
Dilution
IF-Cell: 1:50-1:200;IHC-P: 1:50-1:200;FC: 1:50-1:100
Purity
Immunogen affinity purified.
Form
Liquid
Buffer
1*PBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
Molecular Weight
Predicted band size: 14 kDa
Storage Conditions
Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
Recombinant Antibody
No
CAS Number
9007-83-4
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