CRMP2 Rabbit Polyclonal Antibody
Collapsin response mediator proteins (CRMPs), including CRMP-1 (DRP-1), CRMP-2 (DRP-2 or TOAD64), CRMP-3 (DRP-4), CRMP-4 (DRP-3) and CRMP-5 (DRP-5), mediate signal transduction after exposure of neural cells to the axon guidance molecule Semaphorin 3A (SEMA3A)/collapsin. CRMPs are present in the developing cerebral cortex and neocortical neurons and are responsive to SEMA3A. In the adult brain, the expression of CRMPs is dramatically downregulated. However, they remain expressed in structures that retain their capacity for differentiation and plasticity. CRMP-2 is involved in axonal growth and guidance. The human CRMP-2 gene maps to 8p21.2, a chromosomal region that has been previously shown to have a significant linkage to schizophrenia and to several deficit symptoms of schizophrenia.
Product Specifications
CAS Number
9007-83-4
Product Name Alternative
Abbreviation
DRP-2, CRMP-2, ULIP-2, DPYSL2, CRMP2, ULIP2
Swiss Prot
Q16555 Human, O08553 Mouse
Cellular Locus
Cytosol. Cytoskeleton. Membrane.
Host
Rabbit
Species Reactivity
Human,Mouse
Immunogen
Recombinant protein within Human CRMP2 aa 90-320.
Isotype
IgG
Conjugation
Non-conjugated
Type
Rabbit polyclonal Antibody
Applications
WB, IF-Cell, IHC-P
Positive Control
Mouse brain tissue lysate, SH-SY-5Y, A549, SiHa, human tonsil tissue, human colon tissue, human breast cancer tissue.
Concentration
1 mg/mL
Dilution
WB: 1:1,000-1:10,000;IF-Cell: 1:50-1:200;IHC-P: 1:50-1:200
Purity
Immunogen affinity purified.
Form
Liquid
Buffer
1*PBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
Molecular Weight
Predicted band size: 62 kDa
Storage Conditions
Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
Recombinant Antibody
No
Frequently Asked Questions
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