Iba1 Rabbit Polyclonal Antibody
Ionized calcium-binding adapter molecule 1 (Iba1), also known as allograft inflammatory factor-1 (AIF-1), is a 147 amino acid cytoplasmic, calcium-binding protein that is thought to play a role in macrophage activation and function. Iba1, containing two EF domains, is induced by cytokines and interferons. In an unstimulated state, Iba1 colocalizes with actin, and upon stimulation, translocates to lamellipodia. It is also a marker of human microglia and is expressed by macrophages in injured skeletal muscle. The gene encoding Iba1 maps to chromosome 6p21.33 and resides in the tumor necrosis factor (TNF) cluster of genes located in the region represented by the human major histocompatibility complex (MHC).
Product Specifications
CAS Number
9007-83-4
Product Name Alternative
Abbreviation
AIF-1, AIF1, G1, IBA1
Swiss Prot
P55008 Human, O70200 Mouse
Cellular Locus
Plasma membrane. Cytoskeleton.
Host
Rabbit
Species Reactivity
Human,Mouse
Immunogen
Synthetic peptide within C-terminal human Iba1.
Isotype
IgG
Conjugation
Non-conjugated
Type
Rabbit polyclonal Antibody
Applications
IHC-P
Positive Control
Human tonsil tissue, human spleen tissue, mouse spleen tissue.
Concentration
1 mg/mL
Dilution
IHC-P: 1:50-1:200
Purity
Immunogen affinity purified.
Form
Liquid
Buffer
1*PBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
Molecular Weight
17/10/15 kDa
Storage Conditions
Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Recombinant Antibody
No
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